In a city of inimitable grace and style, The St. Regis luxury San Francisco hotel embodies extraordinary hospitality with modern day sophistication. Only at this legendary San Francisco hotel will guests take pleasure in the signature St. Regis Butler service, ready to attend to every need with discreet precision. Explore our modern luxury of our San Francisco accommodation that puts you in the heart of this lively city. The St. Regis San Francisco hotel enjoys an artful address, with the Museum of the African Diaspora located within the hotel and the Contemporary Jewish Museum. This luxury San Francisco hotel defines the modern day interpretation of the St. Regis legacy that began over a century ago.